The elucidation of protein function is essential to understand biological system and important to find a way to treat a disease. Despite of the significant achievement to investigate the role of proteins in a cell, the exploration of individual protein functions is still challenging due to the complexity of proteome. For example, post-translational modification (PTM) events (e.g., phosphorylation, glycosylation, and ubiquitination) not only alter protein structures, but also modulate protein functions.
We are interested in the development of new biochemical tools which enable us to investigate the function of individual proteins, in particular, a new approach for evaluating how glycosylation events modulate protein functions. To achieve our goals, we endeavor to develop novel chemical reactions allowing us to monitor the change of protein functions upon PTM in a cell, which potentially lead us to find new targets related to a disease such as cancer. Our efforts also focus on the small molecule drug discovery to cure a cancer.